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🧬 What if we could insert healthy genes into th 🧬 What if we could insert healthy genes into the chromosomes of cells without triggering the body's natural defenses? Researchers from the lab of Ben Kleinstiver, PhD, at Mass General Brigham, developed a new genome editing approach called INSTALL, which uses "stealth" single-stranded DNA and specialized enzymes to safely insert large, gene-sized DNA sequences into the genome. In their recent study led by Connor Tou, PhD, the Kleinstiver lab developed INSTALL to enable large-scale DNA insertion without the toxic immune responses often seen with conventional DNA insertion methods. The team's work represents an important step toward more scalable gene therapies that could one day help treat many patients with the same genetic disease, regardless of the specific mutation they carry.

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