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What can the blood vessels inside a tumor tell us What can the blood vessels inside a tumor tell us about colorectal cancer? Mass General Brigham researchers and collaborators analyzed more than 61,000 tumor blood vessels from 837 colorectal cancer patients using advanced imaging and AI-based machine learning. They found that higher overall blood vessel density and a greater proportion of smaller microvessels were associated with better colorectal cancer survival, while certain abnormal vessel features were linked to worse outcomes. The findings suggest that tumor blood vessel characteristics could eventually help researchers better understand cancer biology and develop more precise approaches to treatment. “Our study demonstrated that vascular features could serve as prognostic biomarkers, biological or clinical signs that signal the likely path of a disease,” said author Shuji Ogino, MD, PhD. “It indicates what might have happened in the past or what may happen in the future, no matter what treatment is used." Photo credit: Ogino Lab. Image shows A fluorescent microscope image.

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