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🧠 Could skull bone marrow hold the key to better c 🧠 Could skull bone marrow hold the key to better chronic pain relief?

A new Mass General Brigham study, featured on the cover of Science Translational Medicine, reveals that skull bone marrow activity is significantly altered in adults with chronic low back pain and knee osteoarthritis.

Recent research points to skull bone marrow as a vital bridge between the brain and the immune system, and using PET/MRI imaging, investigators found that higher levels of TSPO, a protein marker associated with inflammation, directly correlated with greater pain intensity, higher levels of anxiety and depression, and increased immune cell density across multiple chronic pain conditions.

“These findings suggest a new direction for pain research,” said study author Marco Loggia, PhD. “Better understanding how the skull bone marrow is involved in chronic pain could lead to new ways to treat pain and reduce its burden on patients.”

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