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During Fertility Awareness Month, we’re shedding During Fertility Awareness Month, we’re shedding light on important research that helps expand how we think about infertility, especially in men. Researchers at Mass General Brigham, led by Maria Agustina Battistone, PhD, are studying how the immune system affects sperm as they mature in the epididymis. Their work shows that chronic, often “silent” inflammation can trigger immune cells to produce anti‑sperm antibodies that damage sperm and reduce fertility. By uncovering how these immune responses develop and persist, Battistone and colleagues aim to improve the diagnosis of unexplained male infertility, identify patients who may benefit from anti-inflammatory or immune‑modulating treatments, and explore the epididymis as a target for non‑hormonal, reversible male contraception.

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