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Still scrambling for a Halloween costume? We’ve go Still scrambling for a Halloween costume? We’ve got some wild ideas! 🐸🦑🦇 Forget vampires and witches. These five animals have real-life superpowers that are inspiring medical research at Mass General Brigham. Swipe for some DIY costume inspiration, and the science behind it! Wood frogs: the original ice royalty! These amphibians can survive the winter partially frozen, then thaw out when temperatures rise. Scientists at Mass General Brigham and colleagues are hoping to replicate this process of “supercooling without freezing” in the lab to better preserve transplantable organs until they can reach their recipients. Freezing the organs outright causes damage from ice crystals, and current cryopreservation agents are too toxic to keep the organs viable. If researchers can devise a method for preserving organs that mirrors what the wood frog does, this could make many more organs available for transplant. Need to escape an awkward conversation at your Halloween party? Take a page from the squid’s playbook. These underwater escape artists can release a cloud of ink to distract predators and make a quick getaway. Inspired by the squid, investigators at Mass General Brigham, along with colleagues at MIT and Novo Nordisk, developed a family of microjet delivery (MiDe) systems that discharge liquid drugs in a precise, powerful stream directly into the gastrointestinal tract without the need for needles. With more research and development, this liquid-based delivery system could be an appealing alternative to needles for patients taking injectable drugs. Zebrafish — small freshwater fish native to India and parts of Asia — have a lot of genetic similarities to humans and are commonly used as a modeling system in medical research. Unlike humans, however, zebrafish have the remarkable ability to completely regenerate their tendons after tears. Mass General Brigham researchers have been studying this process to find ways to help human tendons heal better. Small but mighty! Meet the tardigrade, aka the water bear. These microscopic creatures can survive extreme conditions, including radiation levels that would be deadly to humans. Radiation therapy is

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