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Medicine Changes Lives. Research Changes the World.

Every day, Mass General scientists chart new terrain in biomedical research to prevent and treat human disease and advance patient care — locally and across the globe.

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Sometimes, a single patient can help open the door Sometimes, a single patient can help open the door to an entirely new approach to treating cancer. At just 28 years old, Jacob Sloniker had already undergone multiple surgeries for a rare jaw tumor that continued to return, leaving him with few remaining treatment options. Then he enrolled in a first-in-human clinical trial at the Mass General Brigham Cancer Institute, testing an experimental therapy designed to target the Wnt/β-catenin signaling pathway, a pathway involved in many cancers but long considered difficult to treat safely. More than a year later, Jacob's response has given him something he hadn't had in years: the chance to get back to everyday life. While this is only a single patient in an early-phase clinical trial, researchers say it could represent an important step toward targeting a pathway that plays a role in many types of cancer. “This is the story of only one patient, so we can’t claim victory, but this could be the beginning of hitting a target we weren’t sure was targetable," said Samuel Klempner, MD, who oversaw the clinical trial. "We hope this example is part of how the next wave starts.” Read more at the link in our bio. (Pictured: Jacob Sloniker (right) was a groomsman at his cousin's wedding last September.)

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