Science news and discoveries from the Mass General Research Institute
Bench PressBench PressBench PressBench Press
  • Home
  • About
  • Research
    • COVID-19
    • Brain
    • Heart
    • Cancer
    • More…
  • Communicating Science
  • Events
  • Subscribe

Missing Genes Point to New Drug Targets

    Home Medicine Genetics & Genomics Missing Genes Point to New Drug Targets

    Missing Genes Point to New Drug Targets

    By mghresearch | Genetics & Genomics | 0 comment | 1 May, 2017 | 0

    The Human Genome Project provided a ‘parts-list’ of genes, about 18,000 in number. Now, researchers are studying what it means to be missing a part. In an analysis of the genomes of 10,000 research participants, Mass General’s Dr. Sekar Kathiresan and his research team found 1,300 genes which were broken in at least one participant. For example, several individuals were missing a working copy of the APOC3 gene and as a result, these individuals had lower blood levels of fat and were protected from heart attack.

    Such examples help us understand the function of a gene in humans and also point to new drug targets. This study sets the stage for an ambitious ‘Human Knockout Project’, a systematic effort to understand gene function by identifying and characterizing humans who naturally lack a gene.

    Interested in learning more on this study? Check out this post from the NIH Director’s Blog. For more information about Dr. Kathiresan’s work with Mass General’s Center for Genomic Medicine, visit their website.

    About the Mass General Research Institute
    Massachusetts General Hospital is home to the largest hospital-based research program in the United States. Our researchers work side-by-side with physicians to develop innovative new ways to diagnose, treat and prevent disease.
    Support our research

    No tags.

    Related Post

    • To Mars and Beyond: Exploring Innovative Solutions to the Challenges of Space Travel

      By mghresearch | 1 comment

      If you could only bring two shoeboxes worth of medical supplies—from first aid kits to surgical tools— with you on a three-year space mission, what would you bring?

    • Are You Actually Allergic to Penicillin? Researchers Find New Methods to Confirm Antibiotic Allergies

      By mghresearch | 0 comment

      Mass General researchers are working to increase the safe use of penicillins in patients who have a recorded penicillin allergy but are not actually allergic.

    • Re-Thinking Mental Health Treatment: World Health Day 2017

      By mghresearch | 0 comment

      Did you know that more than 300 million people worldwide live with depression? That number has increased 18% between 2005 and 2015, according to the World Health Organization (WHO). With such staggering numbers, it’s no surprise that WHO has chosen depression as its theme for this year’s World Health Day, which is celebrated today, April 7th.

    • New Study Finds Low-Dose Aspirin May Lower Risk of Cancer Death

      By mghresearch | 1 comment

      A new study from Massachusetts General Hospital reports that long-term regular aspirin was associated with a lower risk of dying from various types of cancers.

    • Mass General Stands Up for Science

      By mghresearch | 0 comment

      The Boston March for Science will celebrate the discovery, understanding and sharing of scientific knowledge. Several groups from Massachusetts General Hospital are working together to organize and ensure a strong presence to reaffirm the message about the essential role that science – biomedical research, in particular – plays in improving life and health.

    • Adhering to Treatment During Adolescence Keeps HIV-Positive Youth on a Healthier Track

      By mghresearch | 0 comment

      Individuals born with HIV are more likely to have difficulty managing their treatment as teens and young adults than they did as children.

    • Celebrating the Role of Women in Science and Much More

      By mghresearch | 2 comments

      Interested in the newest research studies and hot topics? Check out the latest issues of “From the Lab Bench”, a monthly newsletter from the Office of the Scientific Director at the Mass General Research Institute, and “Research Roundup”, our monthly recap of the latest biomedical research news.

    • Research Rumble Recap and the Art of Effective Science Communication

      By mghresearch | 1 comment

      Last night five researchers from Massachusetts General Hospital and Brigham and Women’s Hospital showed off their science communication skills in a Research Rumble at the Cambridge Public Library as part of Cambridge Science Festival. Co-DirectorRead more

    Leave a Comment

    Cancel reply

    Your email address will not be published. Required fields are marked *

    Categories

    Social

    Tags

    adolescents aging allergies ALS artificial intelligence brain health cancer treatments child health cholera clinical research clinical trials community health coronavirus dementia diagnostic tools diversity exercise Harvard health disparities heart attacks heart disease heart failure heart month hypertension image contest innovation internships kidney disease machine learning martinos center memory mental health microbiome Munn Center for Nursing Research nursing PET imaging postdocs public health Ragon Institute rare diseases researchers science writing sleep women's health women in medicine

    Copyright 2020
    Mass General Research Institute
    All Rights Reserved

    SUBSCRIBE TO BENCH PRESS


    Contact

    Mass General Research Institute
    125 Nashua St.
    Boston, MA 02114
    617-724-0200
    researchinstitute@mgh.harvard.edu
    M-F: 9:00 am - 5:00 pm
    • Home
    • About
    • Research
      • Brain
      • Cancer
      • Heart
    • Communicating Science
    • Events
    • Home
    • About
    • Research
      • Brain
      • Cancer
      • Heart
      • More…
    • Communicating Science
    • Events
    Bench Press